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专利名称：Stability assessment of dispersions and
emulsions
发明人：David F. Nicoli,David F. Driscoll,Bruce R.
Bistrian
申请号：US10606959申请日：20030627公开号：US07150996B2公开日：20061219
专利附图：
摘要：A method and apparatus for determining the stability of dispersions andemulsions accelerates the onset of significant particle agglomeration in a sample by
stressing the sample by reducing the height of the interparticle potential energy barrierbetween the particles. This is achieved by adding one or more of three stress factors:changing the pH of the sample to reduce the surface charge on the particles; adding anadsorbing electrolyte so that ions of the appropriate charge are adsorbed onto thesurfaces of the particles to reduce the net charge on the particles; and applying amonovalent, divalent, or trivalent salt to partially screen electrostatic repulsionsbetween the charged particles. In a preferred embodiment, the increase in
agglomeration is detected with single particle detection, such as SPOS, to generate a PSDfrom which a figure of merit is derived. Another embodiment detects turbidity or lightscattering to generate a value X indicative of the extent of agglomeration.
申请人：David F. Nicoli,David F. Driscoll,Bruce R. Bistrian
地址：Goleta CA US,Bridgewater MA US,Ipswich MA US
国籍：US,US,US
代理机构：Buchanan Ingersoll & Rooney
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