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专利名称：Parenteral metolazone formulations发明人：RONALD SANTELLI,YU-HSING TU申请号：AU2971100申请日：20000121公开号：AU2971100A公开日：20000807
摘要：The invention provides a method of making a pharmaceutical compositioncomprising a solution, which method comprises: (a) providing a solvent comprisingpropylene glycol, polyethylene glycol, polypropylene glycol, or glycerin; and (b) addingmetolazone. The final concentration of metolazone in the solution is 9 mg/ml or more,the metolazone is not precipitated, and the concentration of metolazone is above itsapparent equilibrium solubility. The invention also provides a pharmaceutical compositioncomprising a solution comprising: (a) a solvent other than water; and (b) 9 mg/ml or moreof metolazone. The metolazone is not precipitated in this solution and the concentrationof metolazone is above its apparent equilibrium solubility.
申请人：MEDEVA PHARMACEUTICALS MANUFACTURING, INC.
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