专利内容由知识产权出版社提供
专利名称：Antiproliferative vitamin D.sub.3 hybrids发明人：Gary H. Posner申请号：US08/597298申请日：19960206公开号：US05830885A公开日：19981103
摘要：Vitamin D.sub.3 analogues of formula ##STR1## wherein R represents a 1-hydroxyalkyl group or 1-fluoroalkyl group in a trans- configuration with a 3-hydroxylgroup on the A ring and R.sup.2 represents the substituents completing a vitamin D.sub.3analogue. These novel compounds are potent anti-proliferative substances with activitiescomparable to that of calcitriol but with vitamin D.sub.3 receptor binding ratings of lessthan 10.sup.-3 compared to that of calcitriol.
申请人：THE JOHNS HOPKINS UNIVERSITY
代理机构：Cushman Darby & Cushman IP Group of Pillsbury Madison & Sutro
更多信息请下载全文后查看
